The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?

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The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop? / Hansen, Lene; Holst, Jens Juul.

I: Regulatory Peptides, Bind 110, Nr. 1, 31.12.2002, s. 39-45.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, L & Holst, JJ 2002, 'The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?', Regulatory Peptides, bind 110, nr. 1, s. 39-45.

APA

Hansen, L., & Holst, J. J. (2002). The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop? Regulatory Peptides, 110(1), 39-45.

Vancouver

Hansen L, Holst JJ. The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop? Regulatory Peptides. 2002 dec. 31;110(1):39-45.

Author

Hansen, Lene ; Holst, Jens Juul. / The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?. I: Regulatory Peptides. 2002 ; Bind 110, Nr. 1. s. 39-45.

Bibtex

@article{d723d4bbd79e46408d62703a60683d9a,

title = "The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?",

abstract = "Secretion of the gut hormone glucagon-like peptide-1 (GLP-1) is stimulated by meal ingestion. The response is rapid, suggesting a stimulatory pathway elicited from the upper gastrointestinal area. In pigs, we have been unable to demonstrate a neural stimulatory pathway, but GLP-1 secretion is regulated by local somatostatin secretion. In search for an endocrine pathway, we studied the effect of a range of concentrations of cholecystokinin octapeptide (26-33) (CCK 8), gastric inhibitory peptide 1-42 (GIP), secretin, motilin, calcitonin gene-related peptide (CGRP), and the modified amino acid, 5-hydroxytryptamine (serotonin, 5-HT) on GLP-1 and somatostatin release from isolated perfused segments of porcine ileum.GLP-1 secretion was stimulated by 1 nM CCK 8 and 10 nM GIP, but suppressed by 1 nM motilin and 1 microM 5-HT. Secretin and CGRP had no effect. Somatostatin secretion was stimulated by CCK 8 at 1 and 10 nM, by GIP at 1 and 10 nM and by 10 nM CGRP. Secretin, 5-HT and motilin had no effect on somatostatin secretion. We conclude that CCK 8 and GIP 1-42 stimulated GLP-1 secretion, but only in concentrations greatly exceeding normal postprandial concentrations. Thus, we find it unlikely that endocrine agents from the duodenum regulate GLP-1 secretion in pigs.",

keywords = "Animals, Calcitonin Gene-Related Peptide, Chemotherapy, Cancer, Regional Perfusion, Duodenum, Gastric Inhibitory Polypeptide, Gastrointestinal Hormones, Glucagon, Glucagon-Like Peptide 1, Ileum, Motilin, Peptide Fragments, Postprandial Period, Protein Precursors, Sincalide, Swine",

author = "Lene Hansen and Holst, {Jens Juul}",

year = "2002",

month = dec,

day = "31",

language = "English",

volume = "110",

pages = "39--45",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "1",