Endodontic inflammatory disease: A risk indicator for a first myocardial infarction
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Endodontic inflammatory disease : A risk indicator for a first myocardial infarction. / Sebring, Dan; Buhlin, Kåre; Norhammar, Anna; Rydén, Lars; Jonasson, Peter; Lund, Henrik; Kvist, Thomas; Bjørndal, Lars; Dawson, Victoria S.; Fransson, Helena; Frisk, Fredrik; Jonasson, Peter; Markvart, Merete; Pigg, Maria; EndoReCo.
I: International Endodontic Journal, Bind 55, Nr. 1, 2021, s. 6-17.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Endodontic inflammatory disease
T2 - A risk indicator for a first myocardial infarction
AU - Sebring, Dan
AU - Buhlin, Kåre
AU - Norhammar, Anna
AU - Rydén, Lars
AU - Jonasson, Peter
AU - Lund, Henrik
AU - Kvist, Thomas
AU - Bjørndal, Lars
AU - Dawson, Victoria S.
AU - Fransson, Helena
AU - Frisk, Fredrik
AU - Jonasson, Peter
AU - Markvart, Merete
AU - Pigg, Maria
AU - EndoReCo
N1 - Publisher Copyright: © 2021 The Authors. International Endodontic Journal published by John Wiley & Sons Ltd on behalf of British Endodontic Society
PY - 2021
Y1 - 2021
N2 - Aim: To study the association between endodontic inflammatory disease and a first myocardial infarction (MI). Methodology: The study comprised 805 patients with recent experience of a first MI, each gender, age and geographically matched with a control. Panoramic radiographs were available for 797 patients and 796 controls. Endodontic inflammatory disease was assessed radiographically. The sum of decayed, missing and filled teeth (DMFT) was calculated, and the number of root filled teeth and teeth with periapical lesions were recorded. The associated risk of a first MI was expressed as odds ratios (OR) with 95% confidence intervals (CI), unadjusted and adjusted for confounders (family history of cardiovascular disease, smoking habits, marital status, education and diabetes). Results: Patients who had suffered a first MI had higher DMFT (mean 22.5 vs. 21.9, p =.013) and more missing teeth (mean 7.5 vs. 6.3; p <.0001) than the healthy controls. The number of missing teeth was associated with an increased risk of a first MI (adjusted OR 1.04; CI 1.02–1.06). Conversely, decay-free, filled teeth were associated with decreased risk (adjusted OR 0.98; CI 0.96–1.00). Analysis based on age disclosed the following variables to be associated with an increased risk of a first MI: number of decayed teeth (adjusted OR 1.18; CI 1.02–1.37, in patients <60 years), any primary periapical lesion (adjusted OR 1.57; CI 1.08–2.29, in patients <65 years) and the proportion of root filled teeth (adjusted OR 1.18; CI 1.03–1.36, in patients ≥65 years). Conclusions: More missing teeth was independently associated with an increased risk of a first MI. In addition, endodontic inflammatory disease may contribute as an independent risk factor to cardiovascular disease since untreated caries, periapical lesions and root fillings, depending on age, were significantly associated with a first MI.
AB - Aim: To study the association between endodontic inflammatory disease and a first myocardial infarction (MI). Methodology: The study comprised 805 patients with recent experience of a first MI, each gender, age and geographically matched with a control. Panoramic radiographs were available for 797 patients and 796 controls. Endodontic inflammatory disease was assessed radiographically. The sum of decayed, missing and filled teeth (DMFT) was calculated, and the number of root filled teeth and teeth with periapical lesions were recorded. The associated risk of a first MI was expressed as odds ratios (OR) with 95% confidence intervals (CI), unadjusted and adjusted for confounders (family history of cardiovascular disease, smoking habits, marital status, education and diabetes). Results: Patients who had suffered a first MI had higher DMFT (mean 22.5 vs. 21.9, p =.013) and more missing teeth (mean 7.5 vs. 6.3; p <.0001) than the healthy controls. The number of missing teeth was associated with an increased risk of a first MI (adjusted OR 1.04; CI 1.02–1.06). Conversely, decay-free, filled teeth were associated with decreased risk (adjusted OR 0.98; CI 0.96–1.00). Analysis based on age disclosed the following variables to be associated with an increased risk of a first MI: number of decayed teeth (adjusted OR 1.18; CI 1.02–1.37, in patients <60 years), any primary periapical lesion (adjusted OR 1.57; CI 1.08–2.29, in patients <65 years) and the proportion of root filled teeth (adjusted OR 1.18; CI 1.03–1.36, in patients ≥65 years). Conclusions: More missing teeth was independently associated with an increased risk of a first MI. In addition, endodontic inflammatory disease may contribute as an independent risk factor to cardiovascular disease since untreated caries, periapical lesions and root fillings, depending on age, were significantly associated with a first MI.
KW - apical periodontitis
KW - dental caries
KW - endodontics
KW - inflammation
KW - myocardial infarction
KW - oral health
U2 - 10.1111/iej.13634
DO - 10.1111/iej.13634
M3 - Journal article
C2 - 34561889
AN - SCOPUS:85116793838
VL - 55
SP - 6
EP - 17
JO - International Endodontic Journal
JF - International Endodontic Journal
SN - 0143-2885
IS - 1
ER -
ID: 282467228