Bacterial adherence in otitis media: Determination of N-acetylgalactosamine (GalNAc) residues in the submucosal glands and surface epithelium of the normal and diseased Eustachian tube
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Acute otitis media (AOM) is the most common childhood infection caused by bacteria. The pathogenesis of AOM implicates initial adherence of a pathogen to the nasopharyngeal epithelium, which is followed by bacterial colonization of the middle ear cavity through the Eustachian tube. N-acetylgalactosamine (GalNAc) is an important constituent of mucins and GalNAc containing sugar residues seem to be essential for initial adherence of respiratory bacteria to the surface of epithelial cells.
Originalsprog | Engelsk |
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Tidsskrift | Microbial Pathogenesis |
Vol/bind | 51 |
Udgave nummer | 1-2 |
Sider (fra-til) | 48-57 |
Antal sider | 10 |
ISSN | 0882-4010 |
DOI | |
Status | Udgivet - jul. 2011 |
ID: 33544131