Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways

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Standard

Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways. / Kirkeby, Svend; Martel, Cyril Jean-Marie; Aasted, Bent.

I: Virus Research, Bind 144, Nr. 1-2, 2009, s. 225-232.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kirkeby, S, Martel, CJ-M & Aasted, B 2009, 'Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways', Virus Research, bind 144, nr. 1-2, s. 225-232. https://doi.org/10.1016/j.virusres.2009.05.004

APA

Kirkeby, S., Martel, C. J-M., & Aasted, B. (2009). Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways. Virus Research, 144(1-2), 225-232. https://doi.org/10.1016/j.virusres.2009.05.004

Vancouver

Kirkeby S, Martel CJ-M, Aasted B. Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways. Virus Research. 2009;144(1-2):225-232. https://doi.org/10.1016/j.virusres.2009.05.004

Author

Kirkeby, Svend ; Martel, Cyril Jean-Marie ; Aasted, Bent. / Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways. I: Virus Research. 2009 ; Bind 144, Nr. 1-2. s. 225-232.

Bibtex

@article{f314503090a211de8bc9000ea68e967b,
title = "Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways",
abstract = "Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked a2-3 and a2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyla2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyla2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyla2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyla2-3 and Sialyla2-6 epitopes.",
author = "Svend Kirkeby and Martel, {Cyril Jean-Marie} and Bent Aasted",
year = "2009",
doi = "10.1016/j.virusres.2009.05.004",
language = "English",
volume = "144",
pages = "225--232",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways

AU - Kirkeby, Svend

AU - Martel, Cyril Jean-Marie

AU - Aasted, Bent

PY - 2009

Y1 - 2009

N2 - Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked a2-3 and a2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyla2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyla2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyla2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyla2-3 and Sialyla2-6 epitopes.

AB - Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked a2-3 and a2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyla2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyla2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyla2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyla2-3 and Sialyla2-6 epitopes.

U2 - 10.1016/j.virusres.2009.05.004

DO - 10.1016/j.virusres.2009.05.004

M3 - Journal article

C2 - 19447147

VL - 144

SP - 225

EP - 232

JO - Virus Research

JF - Virus Research

SN - 0168-1702

IS - 1-2

ER -

ID: 13924829