IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency
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IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency. / Eriksen, Carsten; Moll, Janne Marie; Myers, Pernille Neve; Pinto, Ana Rosa Almeida; Danneskiold-Samsøe, Niels Banhos; Dehli, Rasmus Ibsen; Rosholm, Lisbeth Buus; Dalgaard, Marlene Danner; Penders, John; Jonkers, Daisy Mae; Pan-Hammarström, Qiang; Hammarström, Lennart; Kristiansen, Karsten; Brix, Susanne.
I: Nature Communications, Bind 14, Nr. 1, 8124, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency
AU - Eriksen, Carsten
AU - Moll, Janne Marie
AU - Myers, Pernille Neve
AU - Pinto, Ana Rosa Almeida
AU - Danneskiold-Samsøe, Niels Banhos
AU - Dehli, Rasmus Ibsen
AU - Rosholm, Lisbeth Buus
AU - Dalgaard, Marlene Danner
AU - Penders, John
AU - Jonkers, Daisy Mae
AU - Pan-Hammarström, Qiang
AU - Hammarström, Lennart
AU - Kristiansen, Karsten
AU - Brix, Susanne
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Immunoglobulin A (IgA) is acknowledged to play a role in the defence of the mucosal barrier by coating microorganisms. Surprisingly, IgA-deficient humans exhibit few infection-related complications, raising the question if the more specific IgG may help IgM in compensating for the lack of IgA. Here we employ a cohort of IgA-deficient humans, each paired with IgA-sufficient household members, to investigate multi-Ig bacterial coating. In IgA-deficient humans, IgM alone, and together with IgG, recapitulate coating of most bacterial families, despite an overall 3.6-fold lower Ig-coating. Bacterial IgG coating is dominated by IgG1 and IgG4. Single-IgG2 bacterial coating is sparse and linked to enhanced Escherichia coli load and TNF-α. Although single-IgG2 coating is 1.6-fold more prevalent in IgA deficiency than in healthy controls, it is 2-fold less prevalent than in inflammatory bowel disease. Altogether we demonstrate that IgG assists IgM in coating of most bacterial families in the absence of IgA and identify single-IgG2 bacterial coating as an inflammatory marker.
AB - Immunoglobulin A (IgA) is acknowledged to play a role in the defence of the mucosal barrier by coating microorganisms. Surprisingly, IgA-deficient humans exhibit few infection-related complications, raising the question if the more specific IgG may help IgM in compensating for the lack of IgA. Here we employ a cohort of IgA-deficient humans, each paired with IgA-sufficient household members, to investigate multi-Ig bacterial coating. In IgA-deficient humans, IgM alone, and together with IgG, recapitulate coating of most bacterial families, despite an overall 3.6-fold lower Ig-coating. Bacterial IgG coating is dominated by IgG1 and IgG4. Single-IgG2 bacterial coating is sparse and linked to enhanced Escherichia coli load and TNF-α. Although single-IgG2 coating is 1.6-fold more prevalent in IgA deficiency than in healthy controls, it is 2-fold less prevalent than in inflammatory bowel disease. Altogether we demonstrate that IgG assists IgM in coating of most bacterial families in the absence of IgA and identify single-IgG2 bacterial coating as an inflammatory marker.
U2 - 10.1038/s41467-023-44007-2
DO - 10.1038/s41467-023-44007-2
M3 - Journal article
C2 - 38065985
AN - SCOPUS:85178941269
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 8124
ER -
ID: 376413982